Continuous Particle Separation Through Deterministic Lateral Displacement
Gravity driven deterministic lateral displacement for suspended particles in a 3D obstacle array
Siqi Du
1Mechanical and Aerospace Engineering Department, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
German Drazer
1Mechanical and Aerospace Engineering Department, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
Received 2016 Apr 25; Accepted 2016 Jul 18.
Abstract
We present a simple modification to enhance the separation ability of deterministic lateral displacement (DLD) systems by expanding the two-dimensional nature of these devices and driving the particles into size-dependent, fully three-dimensional trajectories. Specifically, we drive the particles through an array of long cylindrical posts, such that they not only move parallel to the basal plane of the posts as in traditional two-dimensional DLD systems (in-plane motion), but also along the axial direction of the solid posts (out-of-plane motion). We show that the (projected) in-plane motion of the particles is completely analogous to that observed in 2D-DLD systems. In fact, a theoretical model originally developed for force-driven, two-dimensional DLD systems accurately describes the experimental results. More importantly, we analyze the particles out-of-plane motion and observe, for certain orientations of the driving force, significant differences in the out-of-plane displacement depending on particle size. Therefore, taking advantage of both the in-plane and out-of-plane motion of the particles, it is possible to achieve the simultaneous fractionation of a polydisperse suspension into multiple streams.
Deterministic lateral displacement (DLD) is a popular separation method in microfluidics that can effectively fractionate a polydisperse suspension of particles by driving it through a periodic array of obstacles1. In general, a multi-component suspension would be fractionated into two separate streams, one containing particles smaller than a critical size and the other containing the larger particles2 ,3 ,4 ,5. The critical particle size depends on the geometry of the array and its orientation with respect to the driving flow (or force). In addition to size separation, DLD has been successfully applied in microfluidic systems to separate species with different shapes and deformability6 ,7 ,8 ,9 ,10. It was originally proposed as a flow driven, passive separation method but we have recently shown that active, force-driven DLD (f-DLD) is also effective in separating species by size11 ,12 ,13 and shape10. In the majority of DLD systems the obstacle array is a periodic arrangement of cylindrical posts, but other obstacle shapes have been studied to enhance performance14 or to separate non-spherical particles9. In all cases, however, the separation in DLD devices has been exclusively based on the motion of the suspended particles in the basal plane of the array. As a result, and in spite of many variations9 ,11 ,12 ,14, DLD systems have been limited to binary fractionations, in which the sample stream is split into two fractions. Then, to separate a polydisperse suspension into its individual components it is necessary to use multiple DLD systems in series or a single system in which the geometry/orientation of the array changes (continuously) in the direction of the flow1 ,15 ,16 ,17.
Here, we propose a three-dimensional (3D) extension of DLD systems that inherently overcomes the limitation of binary fractionation by taking advantage of the out-of-plane motion of the suspended particles. Specifically, we investigate an obstacle array with long cylindrical posts in which particles not only move in-plane, that is, in the basal plane of the array, but also out-of-plane, i.e. in the direction along the cylindrical obstacles.
It has been shown in previous work that macroscopic DLD models can facilitate detailed research on the particles motion inside the obstacle array10 ,18 ,19 ,20. Therefore, we designed a macroscopic setup that allows for direct visualization of suspended particles moving through an array of long cylindrical posts. The setup also let us fix an arbitrary orientation between the array of obstacles and the driving force (gravity). Thus, we not only control the orientation of the in-plane component of the driving force with respect to obstacle array, as it is the case in 2D systems, but also the relative magnitude of the in-plane and out-of-plane components of the driving force. We perform experiments with particles of different sizes and for a wide range of force orientations with respect to the obstacle array. In all cases, we observe that the in-plane motion of the particles, that is the motion projected onto the basal plane of the array, is analogous to that found in two-dimensional (2D) DLD systems. In particular, there exists a transition from locked mode, in which particles move along a principal direction of the array, to zigzag mode, in which they follow the external force more closely. Analogous to the 2D-DLD case, the fact that particles of different size transition from locked mode to zigzag mode at different orientations of the driving force is the basis for their in-plane separation. More importantly, we show that the out-of-plane motion of the particles is also size dependent. Therefore, 3D-DLD enables the simultaneous separation both in-plane and out-of-plane, thus increasing resolution and making it possible to fractionate a polydisperse suspension into multiple streams. In fact, we demonstrate the simultaneous separation of particles of three different sizes in the proposed 3D-DLD system.
Materials and Methods
Experimental setup and materials
A schematic view of the experimental setup is presented in Fig. 1. The 3D array of obstacles is created using steel rods (diameter D = 2 mm, McMater-Carr Inc.) arranged in a square array between two parallel acrylic plates (see Fig. 1a). The separation between rods in the array is l = 6 mm, and the separation between the acrylic plates is L = 14 cm. The two acrylic plates are fixed on a square acrylic base so that the obstacle array can be rotated as one solid object. The obstacle array is then placed on a supporting rectangular acrylic plate that can be tilted to an arbitrary angle θ with respect to a level surface (see Fig. 1b). In addition, the base can be arbitrarily rotated an angle φ with respect to the supporting plate, as shown in Fig. 1c. The tilt angle, θ, and the rotation angle, φ, let us control the orientation of the obstacle array with respect to gravity.
Schematic view of the experimental setup.
(a) Perspective view. (b) Side view for a rotation angle φ = 0°. (c) Top view of the rotating obstacle array on the supporting plate.
We then place our 3D-DLD system into a container filled with corn oil (viscosity μ = 52.3 mPa · s, density ρ f = 0.926 g/cm3). We performed experiments covering tilt angles from 15.8° to 32.0°, and the rotation angle is varied (approximately) between 5° and 85°, depending on particle size. In each experiment, we fix the slope and rotation angles and release particles individually into the system, to eliminate particle-particle interactions. We use nylon particles with diameters d = 1.59, 2.38 and 3.16 mm (McMater-Carr Inc.), and a total of 20–30 particles are tracked in each experiment. The density of the particles is ρ s = 1.135 g/cm3. The particle Reynolds number in our system is given by where U is the characteristic velocity of the particles. The largest value, estimated using the average sedimenting speed of the largest particles (U = 3.6 mm/s), is Rep ~ 0.2. The Stokes number is given by , and the corresponding maximum value is thus estimated to be St ~ 0.03. We note that these values are consistent with those typically found in microfluidic systems.
Problem geometry and coordinate system
As shown in Fig. 1a, the X and Z axes define the basal plane of the obstacles, and the Y axis is taken as the direction parallel to the cylindrical posts (parallel to their axes). Figure 2a is a schematic representation of two typical trajectories followed by particles inside the 3D obstacle array, one corresponding to zigzag mode (small circles) and the other one corresponding to locked mode (large circles). Figure 2b shows the projection of the trajectories onto the XZ plane.
When projected onto the XZ plane, particle trajectories can be compared to the 2D case. To this end, we determine the forcing angle in the XZ plane, α, i.e. the angle between the in-plane projection of the force acting on the particles and the Z axis, and the migration angle in the XZ plane, β, i.e. the angle between the projected trajectory (onto the XZ plane) and the Z axis (see Fig. 2b). The different components of the driving force (gravity) can be written in the terms of the slope angle θ and the rotation angle φ as follows (see Fig. 2b,c,d):
The forcing angle in the XZ plane is therefore given by
Note that for a fixed tilt angle θ, the possible forcing angles that can be obtained by varying the rotation angle φ are limited to 0 <α <θ.
Results and Discussion
Particle in-plane motion and comparison with 2D-DLD
In previous work, we have shown that particles moving in zigzag mode have periodic trajectories. The periodicity of a trajectory is described by its average direction [p, q], where p, q are Miller indices. For example, in Fig. 2b, the small circles represent a particle moving inside the obstacle array with periodicity [1, 2]. Particles moving in locked mode, represented by the large circles in Fig. 2b, move along a column of obstacles, or a lane, in the array with periodicity [1, 0]. (A column of obstacles is a series of obstacles aligned in the Z-direction, and two such columns delimit a lane in the array). In 2D-DLD, particles of all sizes were observed to transition from locked mode (periodicity [1, 0]) to zigzag mode (with a different periodicity), as the forcing angle increases from α = 0°11 ,21. The angle at which the transition occurs is defined as the critical angle α c and, in principle, it is different for each type of particle21.
To investigate the presence of similar locked-to-zigzag transitions in the 3D-DLD system, we study the probability of crossing, P c , defined as the fraction of a given size of particles that move in zigzag mode out of the total number of those particles in a given experiment. In Fig. 3, we plot P c as a function of the forcing angle for the different particles considered here. Consistent with 2D-DLD results, we observe sharp transitions in the crossing probability for all particle sizes. Another manifestation of these critical transitions is the presence of large variations in the migration angle when the forcing angle is close to α c , due to the discontinuous nature of the change in the migration angle, as indicated by the large error bars in the experimental data close to the transition. We estimate the critical angle α c for each particle size as the forcing angle where its probability of crossing is equal to 1/2, calculated using a linear fit of the intermediate P c values (see Fig. 3). For 1.59, 2.38, and 3.16 mm particles the estimated values of the critical angle are 6.7° ± 1.7°, 10.0° ± 1.5° and 12.6° ± 1.7°, respectively. Also analogous to the 2D case, the critical angle increases with particle size, which enables size-based separation. In addition, we observe that for the same size of particles, the experimental results obtained with different tilt angles collapse into a single curve, which is consistent with the in-plane motion of the particles being independent of the out-of-plane motion. This is expected for the motion of a suspended particle past an array of posts at low Reynolds numbers, as long as particle-obstacle non-hydrodynamic interactions can be approximated by hard-core repulsion forces21 ,22 ,23.
Probability of crossing as a function of the forcing angle.
Different symbols correspond to different particle sizes and slope angles as indicated. Error bars represent the standard deviation of the experimental data.
In Fig. 4, we show the migration angle as a function of forcing angle for all the particles. As expected, for forcing angles smaller than the critical angle, the migration angle remains locked at β = 0°, i.e. particles are moving in locked mode. For forcing angles larger than the critical angle, particles migrate in zigzag mode with β > 0°. Again, we observe that the migration angle is independent of the tilt angle, which suggests that the in-plane motion of the particles is in fact independent from the out-of-plane dynamics. Figure 4 also shows that, when particles are moving in zigzag mode, their migration is not necessarily aligned with the driving force. In fact, Fig. 4 shows clear 'plateaus' in the migration angle vs. forcing angle curves, indicating a constant migration angle for finite intervals of the forcing angle. This phenomenon, known as directional locking, is also present in the 2D case24.
Migration angles as a function of forcing angle.
Different symbols correspond to different particle sizes and slope angles as indicated. The dashed line represents β = α. The migration angles corresponding to directions [1, 0], [1, 2] and [1, 3] are indicated. Error bars represent the standard deviation of the experimental data.
Migration model
Let us consider a model originally developed for 2D-DLD systems based on the assumption that a suspended particle only interacts with a single obstacle at a time (dilute limit). The trajectory of the particles is therefore determined by a sequence of individual particle-obstacle collisions21 ,25 ,26. For each individual particle-obstacle collision, the effect of the short-range non-hydrodynamic repulsive forces between the particle and the obstacle is approximated by a hard-core potential. The hard-core repulsion prevents particles from coming closer to the obstacles than a given minimum separation, but it does not affect the particle trajectory otherwise. It is also important to note that, in the absence of inertia effects (i.e. at low Reynolds numbers) the minimum separation between the particle surface and the obstacle during a particle-obstacle collision is uniquely determined by the incoming offset b in (see Fig. 5). Therefore, for each particle size, we can define a critical incoming offset b c as the incoming offset leading to the minimum separation set by the hard-core repulsion. Then, collisions can be divided into two groups, subject to the relation between b in and b c . Collisions for which b in >b c , are reversible, particle trajectories are fore-and-aft symmetric and hence there is no net lateral displacement after the suspended particle moves past the obstacle. On the other hand, collisions for which b in ≤b c (represented by the shaded region in the schematic views presented in Fig. 5) are irreversible and their outgoing offset is always b c . That is, irreversible collisions result in a net lateral displacement of magnitude |b c −b in |. The fact that particles colliding with an obstacle with b in ≤b c , i.e. inside the shaded area in shown in Fig. 5, come out of the collision with the same offset b c results in directional locking.
Schematic view of possible outcomes of a particle-obstacle irreversible collision depending on the magnitude of the lateral shift between obstacles l sin α compared to the critical impact parameter b c .
Note that collisions are irreversible, b in <b c (shaded area), and particles come out of the interaction with the outgoing offset equal to the critical impact parameter b c . (a) A forcing angle such that l sin α <b c , resulting in particles migrating in locked mode. (b) Forcing at the critical angle, i.e. l sin α =b c , and particles coming out of an irreversible collision approach the next collision head on. (c) A forcing angle corresponding to l sin α >b c , which leads to particles migrating in zigzag mode.
Figure 5 shows three schematic trajectories illustrating the locked-to-zigzag transition according to the collision model just introduced. First, when the lateral displacement between two neighboring obstacles, l sin α, is less than b c . as shown in Fig. 5a, particles will be continuously displaced by successive obstacles due to irreversible collisions. That is, in this case particles will migrate in locked mode and along a column of obstacles as indicated. The mode transition takes place when the forcing angle increases past its critical value, which depends on the particle-obstacle pair. A situation in which particles are driven exactly at the critical forcing angle is shown in Fig. 5b. This corresponds to a particle coming out of an irreversible collision and heading into the next collision with b in = 0, as shown in the figure, which explains the sharp nature of the transitions. On the other hand, when l sin α >b c (Fig. 5c), particles coming out of an irreversible collision will cross through their original obstacle column, i.e. they move in zigzag mode. Given b c , and assuming that successive collisions are independent, the model predicts the migration angle at any forcing angle. Therefore, and in addition to the set of critical angles calculated from the crossing probability, we obtain a second estimate of the critical angle for each particle size by fitting the average migration angles with the proposed model (where b c is the only fitting parameter). The results are plotted in Fig. 6, where we observe good agreement between experiments and the proposed model. The two sets of b c values are reported in Table 1. We note that, due to the discontinuous and staircase-like nature of the curves, the fit of the experimental migration angles results in a range of critical offsets. We represent these ranges by the dashed lines in Fig. 6b,c. For 1.59 mm particles, however, the resulting range is smaller than our resolution and we do not include it in the plot. The corresponding uncertainty in the b c values is also indicated in Table 1.
Table 1
Particle Size d [mm] | b c from P c [mm] | b c from model [mm] |
---|---|---|
1.59 | 0.70 ± 0.18 | 0.61 |
2.38 | 1.04 ± 0.15 | 1.24 ± 0.04 |
3.16 | 1.31 ± 0.17 | 1.57 ± 0.03 |
Three-dimensional deterministic lateral displacement (3D-DLD)
We now consider the possible separative nature of the out-of-plane motion of the particles. In order to compare the motion of different particles, as well as its dependence on the forcing direction, we consider the out-of-plane displacement normalized by the in-plane displacement along the Z axis to obtain Δy/Δz. In Fig. 7, we show the normalized out-of-plane displacement as a function of the in-plane forcing angle for all sizes of particles and for tilt angles θ = 20.5, 26.3 and 32.0°. As indicated in the plots, for all particle sizes, the normalized out-of-plane displacement peaks around their individual critical angles. This suggests that the particle in-plane motion significantly affects the out-of-plane displacement. When the in-plane forcing angle is close to its critical angle, particles tend to stay close to the obstacle longer, slowing down its in-plane-motion and resulting in a large out-of-plane displacement. As a result, we observe that for forcing angles <20°, particles of different size can be separated by taking advantage of the differences in their out-of-plane displacement.
Finally, we demonstrate the simultaneous fractionation of all three sizes of particles by harnessing the out-of-plane separative displacement discussed above. To this end, we consider a forcing angle α ≅ 12°. According to Fig. 3, with this forcing angle, the 3.16 mm particles migrate in locked mode, while the 2.38 and 1.59 mm particles migrate in zigzag mode. This results in the in-plane separation of the largest particles from the rest. On the other hand, the 2.38 and 1.59 mm particles could not be separated based on the in-plane motion alone. This is, in fact, a typical situation in 2D-DLD systems, and usually limits the separation that can be performed to the binary fractionation of a complex suspension into two streams. On the other hand, Fig. 7b, for example, shows that 1.59 and 2.38 mm particles would have a significant difference in their out-of-plane displacement, which enables their fractionation. In order to demonstrate the advantages of 3D-DLD we have also quantified the quality of this test separation. To this end, we added a collector at the bottom of our experimental setup (see Fig. 8). The collector is partitioned into three sections, based on our previous experiments, with an in-plane separation board, perpendicular to X, that would separate the 3.16 mm particles from the rest, and an out-of-plane separation board, perpendicular to Y, that separated between the 1.59 and 2.38 mm particles. The location of the out-of-plane board is determined with respect to the entrance point of the particles and indicated by l 1 in Fig. 8. The results are provided in terms of n αβ the number of particles of type α in the collection bin designed to capture particles of type β. We can then define the efficiency of the separation of particles of a given type as the fraction of such particles in the corresponding collection bin, e α =n αα /∑ β n αβ , and the purity of the separation of particles of a given type as the fraction of particles of this type out of the total number of particles in the corresponding bin, p α =n αα /∑ β n βα .
Schematic view for the placement of the particle collector.
Bin 1, 2 and 3 are designed to collect 3.16, 2.38 and 1.59 mm particles, respectively.
We first perform experiments by releasing one particle at a time into the device, in order to avoid particle-particle interactions, and the results are presented in Table 2. We obtain excellent separation results, with efficiencies ≥95% and purities ≥89%. Then, in order to increase the throughput of the separation, we performed exploratory experiments introducing a mixture of 3–6 particles of different sizes at the same time and the results are presented in Table 3. Although both efficiency and purity values are still reasonably high, a clear reduction is observed, which suggests that further experiments are needed to investigate throughput limitations of the proposed system.
Table 2
Particle Size | 1.59 mm | 2.38 mm | 3.16 mm | Purity |
---|---|---|---|---|
Bin Number | ||||
1 | 1 | 1 | 17 | 89% |
2 | 0 | 21 | 0 | 100% |
3 | 24 | 0 | 0 | 100% |
Efficiency | 96% | 95% | 100% |
Table 3
Particle size | 1.59 mm | 2.38 mm | 3.16 mm | Purity |
---|---|---|---|---|
Bin number | ||||
1 | 0 | 1 | 17 | 94% |
2 | 5 | 22 | 0 | 82% |
3 | 18 | 2 | 0 | 90% |
Efficiency | 78% | 88% | 100% |
Conclusions
We presented a straightforward approach to enhance separation in DLD systems, based on extending the traditionally 2D method into the third dimension by using an array of long cylindrical posts. First, we demonstrated that when projected onto the basal plane of the array, the particles in-plane migration patterns are analogous to those present in the force-driven 2D-DLD case. We observed the existence of a locked mode when the forcing angle is relatively small, and a sharp transition into zigzag mode when the forcing angle is increased past a critical value (critical angle). The fact that the critical angle depends on particle size enables the in-plane fractionation. We also observed that the particles in-plane trajectories are independent of the out-of-plane motion. More important for separation, we observed that the particle out-of-plane displacement does depend on the in-plane motion, with the largest displacements for each type of particle observed when the forcing angle is close to the corresponding critical value. Therefore, the differences in critical angle with particle size not only enable in-plane separation but also lead to different out-of-plane displacements that can be harnessed to enhance the separation ability of DLD systems. We in fact demonstrated that a polydisperse suspension containing three different sizes of particles can be fractionated into its individual components using the proposed 3D-DLD system, with excellent efficiency and purity. Finally, we note that increasing separation throughput lead to a reduction in separation quality and further experiments are needed to explore the effect of particle-particle interactions in the proposed 3D-DLD system.
Additional Information
How to cite this article: Du, S. and Drazer, G. Gravity driven deterministic lateral displacement for suspended particles in a 3D obstacle array. Sci. Rep. 6, 31428; doi: 10.1038/srep31428 (2016).
Acknowledgments
This research is partially funded by the National Science Foundation Grant No. CBET-1339087.
Footnotes
Author Contributions S.D. and G.D. conceived the experiments. S.D. built the experimental setup and conducted the experiments. S.D. and G.D. analyzed the results. Both authors wrote and reviewed the manuscript.
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